Apparent Horizons with Nontrivial Topology and the Hyperhoop Conjecture in Six-Dimensional Space-Times

We investigate the validity of the hyperhoop conjecture, which claims to determine a necessary and sufficient condition for the formation of black hole horizons in higher-dimensional space-times. Here we consider momentarily static, conformally flat initial data sets each describing a gravitational field of uniform massive k-sphere sources, for k=1,2, on the five-dimensional Cauchy surface. The numerical result shows the validity of the hyperhoop conjecture for a wide range of model parameters. We also confirm for the first time the existence of an apparent horizon homeomorphism to S**2 x S**2 or S**1 x S**3, which is a higher-dimensional generalization of the black ring.Comment: 17 pages, 12 figures. to appear in Phys. Rev.

Symmetry breaking and other phenomena in the optimization of eigenvalues for composite membranes

We consider the following eigenvalue optimization problem: Given a bounded domain $\Omega\subset\R^n$ and numbers $\alpha\geq 0$, $A\in [0,|\Omega|]$, find a subset $D\subset\Omega$ of area $A$ for which the first Dirichlet eigenvalue of the operator $-\Delta + \alpha \chi_D$ is as small as possible. We prove existence of solutions and investigate their qualitative properties. For example, we show that for some symmetric domains (thin annuli and dumbbells with narrow handle) optimal solutions must possess fewer symmetries than $\Omega$; on the other hand, for convex $\Omega$ reflection symmetries are preserved. Also, we present numerical results and formulate some conjectures suggested by them.Comment: 24 pages; 3 figures (as separate files); (shortened previous version); to appear in Comm. Math. Phy

Disorder-induced topological change of the superconducting gap structure in iron pnictides

In superconductors with unconventional pairing mechanisms, the energy gap in the excitation spectrum often has nodes, which allow quasiparticle excitations at low energies. In many cases, e.g. $d$-wave cuprate superconductors, the position and topology of nodes are imposed by the symmetry, and thus the presence of gapless excitations is protected against disorder. Here we report on the observation of distinct changes in the gap structure of iron-pnictide superconductors with increasing impurity scattering. By the successive introduction of nonmagnetic point defects into BaFe$_2$(As$_{1-x}$P$_x$)$_2$ crystals via electron irradiation, we find from the low-temperature penetration depth measurements that the nodal state changes to a nodeless state with fully gapped excitations. Moreover, under further irradiation the gapped state evolves into another gapless state, providing bulk evidence of unconventional sign-changing $s$-wave superconductivity. This demonstrates that the topology of the superconducting gap can be controlled by disorder, which is a strikingly unique feature of iron pnictides.Comment: 5 pages, 4 figure

Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia

advance online publication, February 25, 2014Juvenile myelomonocytic leukemia (JMML) is a fatal, mixed myeloproliferative and myelodysplastic disorder occurring in infancy and early childhood. Children with JMML have mutually exclusive genetic abnormalities in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathways, inactivation of the NF1 or mutations in PTPN11, NRAS, KRAS and CBL. A whole-exome sequencing study, performed by Sakaguchi et al.,3 has recently demonstrated that in addition to the high frequency of RAS pathway mutations, mutations in SETBP1 and JAK3 are common recurrent secondary events, and that these events may be involved in tumor progression, and are associated with poor clinical outcomes.ArticleLEUKEMIA. 28(7):1545-1548 (2014)journal articl